Can Ehlers Danlos Cause Seizures?

Yes, EDS may cause seizures in severe conditions. Epilepsy is a typical neurological manifestation of EDS.

EDS is characterized by focal seizures with temporo-parieto-occipital auras. The most common EEG findings are epileptiform discharges and slow, intermittent rhythm with delta-theta waves as the most common EEG findings.

Epilepsy in EDS patients is typically amenable to standard antiepileptic therapy; only a small number of cases of drug-resistant focal epilepsy required surgical intervention, with excellent outcomes in terms of outcome in most cases. Epilepsy is the most prevalent neurological manifestation linked with PH in people with EDS, and it is also the most severe. Patients with PH may develop seizures due to abnormal anatomic circuitries (which may include heterotopic nodules).

Epilepsy and Parkinson’s disease (PH) are two of the most common neurological manifestations that might significantly impact the long-term evolution of these patients’ conditions. Patients with EDS may experience epileptic manifestations due to their PH; nevertheless, much more research is needed to understand the association between nodules and epileptic manifestations in EDS conditions.

Seizures in AVM EDS:

Arterial dissections are ruptures that occur along with the layers of tissue that make up the thickness of the artery. They can occur spontaneously or be preceded by an aneurysm (an abnormal bulge in the diameter of a vessel) or an arterio-venous malformation (unnatural creation of a vein in the artery) (AVM, strange connection between arteries and veins in the body). These bleeds have the potential to be life-threatening. People with AVM EDS experience a carotid-cavernous sinus fistula. An improper link exists between the carotid artery and the cavernous sinuses.

AVM can cause severe headaches and seizures and increase the likelihood of a patient having a stroke. Varicose veins, which are abnormally enlarged and twisted veins visible beneath the skin and can be painful, appear at an early age. The use of vEDS raises the possibility of spontaneous rupture of specific membranes and tissues. Acute stomach or flank discomfort may indicate an artery or intestine rupture, and such symptoms necessitate the immediate provision of emergency medical assistance. Pregnancies should be considered high-risk, and patients should be continuously monitored for artery and uterine ruptures, among other things. As a result, those impacted may be more susceptible to having specific issues during and after surgical operations, such as separating the layers of a surgical wound, than others (dehiscence). The usual life expectancy for people with vEDS is 50 years; however, this age can be significantly increased with careful monitoring and management of problems.

Case study:

A complex inherited connective tissue illness, Ehlers-Danlos syndrome (EDS), is uncommonly associated with epilepsy but has been documented in connection with other disorders.

These seven individuals, who range in age from 28 to 70 years and have EDS as well as epilepsy, are presented in this case study. Two patients were diagnosed with occipital horn syndrome (EDS type IX) and had partial seizures that appeared to be related to the supplementary motor region. In one of these two cases, the patient had an area of frontal gliosis and could reduce the severity of his seizures by hyperextending his neck; in the other case, the patient had a Dandy-Walker deformity was also experiencing pseudoseizures. The third patient in the series suffered from complex partial seizures, pain a symbolic, and basilar artery hypoplasia, all of which were treated successfully. The fourth had ictal aphasia, left hemisphere hypotrophy, and distal right arm and left leg atrophy, among other manifestations of the condition. On examination, the fifth patient was found to have focal seizures, a parietal angioma, hyperekplexia, nocturnal head oscillations (Cjactatio Capitis Nocturna), monoclonal gammopathy-associated neuropathy, and Tourette syndrome. Following an intracranial bleed, the sixth patient developed the effective disease, chronic tiredness, and complex partial seizures with autoscopic symptoms. The seventh patient had previously suffered from a stroke, peripheral neuropathy, and grand mal seizures, among other things.


EDS may be followed by congenital or acquired central nervous system problems that cause severe seizures and epilepsy, and other symptoms. Patients with EDS may also be affected by other neurologic problems that are unrelated to the disease.

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